Motif ID: SOX{8,9,10}.p2

Z-value: 1.165


Transcription factors associated with SOX{8,9,10}.p2:

Gene SymbolEntrez IDGene Name
SOX10 6663 SRY (sex determining region Y)-box 10
SOX8 30812 SRY (sex determining region Y)-box 8
SOX9 6662 SRY (sex determining region Y)-box 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX10chr22_-_383805380.658.0e-02Click!
SOX9chr17_+_701171540.512.0e-01Click!
SOX8chr16_+_1032063,
chr16_+_1031807		-0.502.1e-01Click!


Activity profile for motif SOX{8,9,10}.p2.

activity profile for motif SOX{8,9,10}.p2


Sorted Z-values histogram for motif SOX{8,9,10}.p2

Sorted Z-values for motif SOX{8,9,10}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX{8,9,10}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_8815266 2.539 MFAP5
microfibrillar associated protein 5
chr10_-_105845619 1.994 NM_000494
 COL17A1
collagen, type XVII, alpha 1
chr12_-_52886971 1.947 NM_005554
 KRT6A
keratin 6A
chr18_-_74728677 1.878 MBP
myelin basic protein
chr10_-_105845556 1.862 COL17A1
collagen, type XVII, alpha 1
chr12_-_8815370 1.830 NM_003480
 MFAP5
microfibrillar associated protein 5
chr1_+_209602164 1.620 NM_001104548
 MIR205HG
MIR205 host gene (non-protein coding)
chr15_+_41136622 1.578 NM_001032367
 SPINT1
serine peptidase inhibitor, Kunitz type 1
chr20_+_58179601 1.448 NM_080672
 PHACTR3
phosphatase and actin regulator 3
chr10_-_123356158 1.270 NM_001144915
 FGFR2
fibroblast growth factor receptor 2
chr12_-_8815479 1.268 MFAP5
microfibrillar associated protein 5
chr2_-_161056762 1.264 ITGB6
integrin, beta 6
chr1_+_153003677 1.238 NM_003125
 SPRR1B
small proline-rich protein 1B
chr10_-_103874661 1.127 NM_003893
 LDB1
LIM domain binding 1
chr15_+_41136178 1.111 NM_003710
NM_181642
 SPINT1

serine peptidase inhibitor, Kunitz type 1

chr11_-_16424391 1.103 NM_001145819
NM_017508
 SOX6

SRY (sex determining region Y)-box 6

chr5_-_176836488 0.996 F12
coagulation factor XII (Hageman factor)
chr5_+_140213968 0.981 NM_018910
NM_031852
 PCDHA7

protocadherin alpha 7

chr8_+_95653340 0.973 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
 ESRP1




epithelial splicing regulatory protein 1




chr17_-_39942937 0.973 NM_002230
NM_021991
 JUP

junction plakoglobin


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
1.64 4.55e-03 GO:0010628 positive regulation of gene expression
1.62 3.03e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.62 2.07e-02 GO:0045893 positive regulation of transcription, DNA-dependent
1.56 2.46e-02 GO:2000026 regulation of multicellular organismal development
1.53 1.57e-02 GO:0009888 tissue development
1.52 2.78e-02 GO:0009891 positive regulation of biosynthetic process
1.51 4.35e-02 GO:0051128 regulation of cellular component organization
1.50 2.98e-05 GO:0007399 nervous system development
1.48 1.05e-02 GO:0022607 cellular component assembly
1.43 3.26e-02 GO:0044085 cellular component biogenesis
1.41 4.14e-05 GO:0030154 cell differentiation
1.40 8.32e-08 GO:0048731 system development
1.40 7.73e-05 GO:0048869 cellular developmental process
1.39 9.08e-10 GO:0007275 multicellular organismal development
1.38 1.59e-03 GO:0048513 organ development
1.37 8.18e-08 GO:0048856 anatomical structure development
1.37 1.60e-02 GO:0006996 organelle organization
1.36 1.07e-09 GO:0032502 developmental process
1.33 5.01e-04 GO:0071842 cellular component organization at cellular level
1.31 9.83e-04 GO:0071841 cellular component organization or biogenesis at cellular level

Gene overrepresentation in compartment category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
4.89 3.86e-02 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
1.39 5.96e-03 GO:0005654 nucleoplasm
1.36 5.90e-04 GO:0031981 nuclear lumen
1.34 3.43e-04 GO:0044428 nuclear part
1.29 4.94e-03 GO:0043233 organelle lumen
1.27 1.14e-02 GO:0031974 membrane-enclosed lumen
1.27 1.69e-02 GO:0070013 intracellular organelle lumen
1.16 4.70e-03 GO:0005634 nucleus

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
1.27 1.49e-02 GO:0003677 DNA binding
1.12 3.46e-02 GO:0005515 protein binding
1.07 2.33e-02 GO:0005488 binding